Hypothetica.
Experimental science, disaggregated
A body for the mind of the AI-scientist

Hypothetica is bringing experimental science within reach of AI.

Hypothetica is designing standards-based decentralization of experimental science. AI is already formulating hypotheses, designing experiments, and analyzing data — what's missing is execution in the physical world, a body for the mind of the AI-scientist. We are developing scalable, general-purpose approaches to disaggregate experimental workflows into programmable, interoperable elements.

Why it matters

Networked, decentralized science demands interoperability — not just reproducible end results, but composable processes: standard ways to describe experiments and invoke their operations, so discrete elements assemble into integrated workflows. This lands at a moment of exploding complexity in biological measurement — frontier platforms producing spatially resolved, high-dimensional, dynamic readouts down to single cells. New metrology is needed to make those results trustworthy and networkable.

Who

Founded by Marc Salit, who brings 40+ years in metrology and standards-development innovation — bringing the rigor of physical-science precision measurement to biology at the dawn of the genomics era. Hypothetica builds on this experience to create the network that brings experimental science within reach of AI.

ERCC
Founded & led the External RNA Controls Consortium
GIAB
Founded & led the Genome in a Bottle Consortium
NIST
Built & led the Genome-Scale Measurements Group
JIMB
Joint Initiative for Metrology in Biology, with Stanford
Contact
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